HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
Epigenetic control of HIV-1 post integration latency: implications for therapy
With the development of effective combined anti-retroviral therapy (cART), there is significant
reduction in deaths associated with human immunodeficiency virus type 1 (HIV-1) infection …
reduction in deaths associated with human immunodeficiency virus type 1 (HIV-1) infection …
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size
Chediak–Higashi syndrome (CHS) is a rare, autosomal recessive disorder caused by
biallelic mutations in the lysosomal trafficking regulator (LYST) gene. Even though enlarged …
biallelic mutations in the lysosomal trafficking regulator (LYST) gene. Even though enlarged …
Transcription: insights from the HIV-1 promoter
E Ne, RJ Palstra, T Mahmoudi - International review of cell and molecular …, 2018 - Elsevier
In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
Epigenetic mechanisms of HIV-1 persistence
R Verdikt, O Hernalsteens, C Van Lint - Vaccines, 2021 - mdpi.com
Eradicating HIV-1 in infected individuals will not be possible without addressing the
persistence of the virus in its multiple reservoirs. In this context, the molecular …
persistence of the virus in its multiple reservoirs. In this context, the molecular …
Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
Q Cheng, N Shah, A Bröer… - British journal of …, 2017 - Wiley Online Library
Background and Purpose The neutral amino acid transporter B0AT1 (SLC6A19) has
recently been identified as a possible target to treat type 2 diabetes and related disorders …
recently been identified as a possible target to treat type 2 diabetes and related disorders …
Emerging approaches for histone deacetylase inhibitor drug discovery
Introduction: Histone deacetylases (HDACs) are key players in the mediation of gene
expression for both cancerous and noncancerous malignancies. Overexpression of these …
expression for both cancerous and noncancerous malignancies. Overexpression of these …
Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells
F Wightman, HK Lu, AE Solomon, S Saleh, AN Harman… - Aids, 2013 - journals.lww.com
Objectives: To compare the potency, toxicity and mechanism of action of multiple histone
deacetylase inhibitors (HDACi) in activating HIV production from latency. Design: In-vitro …
deacetylase inhibitors (HDACi) in activating HIV production from latency. Design: In-vitro …
M1 polarization of human monocyte-derived macrophages restricts pre and postintegration steps of HIV-1 replication
Objective: Functional polarization of human monocyte-derived macrophages (MDMs) into
M1 cells leads to inhibition of R5 HIV-1 replication and viral DNA synthesis in comparison to …
M1 cells leads to inhibition of R5 HIV-1 replication and viral DNA synthesis in comparison to …
The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation
XL Liu, Y Yang, Y Hu, J Wu, C Han, Q Lu, X Gan, S Qi… - Elife, 2023 - elifesciences.org
Circadian clocks are evolved to adapt to the daily environmental changes under different
conditions. The ability to maintain circadian clock functions in response to various stresses …
conditions. The ability to maintain circadian clock functions in response to various stresses …