Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

Abstract β-Glucosidases (3.2. 1.21) are found in all domains of living organisms, where they
play essential roles in the removal of nonreducing terminal glucosyl residues from …

Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal
storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's …

Objective: Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor
for develo** Parkinson disease (PD). We investigated the enzymatic activity of …

The molecular machinery responsible for the generation of transport carriers moving from
the Golgi complex to the plasma membrane relies on a tight interplay between proteins and …

The discovery of the glycosphingolipids is generally attributed to Johan LW Thudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

Abstract β-Glucosidases (3.2. 1.21) are found in all domains of living organisms, where they
play essential roles in the removal of nonreducing terminal glucosyl residues from …

A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in
the pathogenesis of insulin resistance. We have developed a highly specific small molecule …

Sesame (Sesamum indicum L.) is an important oil crop renowned for its high oil content and
quality. Recently, genome assemblies for five sesame varieties including two landraces (S …

Glycosphingolipids are controlled by the spatial organization of their metabolism and by
transport specificity. Using immunoelectron microscopy, we localize to the Golgi stack the …