Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Synthetic MRI: technologies and applications in neuroradiology

S Ji, D Yang, J Lee, SH Choi, H Kim… - Journal of Magnetic …, 2022 - Wiley Online Library
Synthetic MRI is a technique that synthesizes contrast‐weighted images from multicontrast
MRI data. There have been advances in synthetic MRI since the technique was introduced …

Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

A Hagiwara, M Hori, K Kamagata, M Warntjes… - Scientific reports, 2018 - nature.com
Magnetization transfer (MT) imaging has been widely used for estimating myelin content in
the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 …

Review of synthetic MRI in pediatric brains: Basic principle of MR quantification, its features, clinical applications, and limitations

C Andica, A Hagiwara, M Hori, K Kamagata… - Journal of …, 2019 - Elsevier
Quantitative magnetic resonance imaging (MRI) with multislice, multi-echo, and multi-delay
acquisition enables simultaneous quantification of R 1 and R 2 relaxation rates, proton …

[HTML][HTML] Age-related changes in relaxation times, proton density, myelin, and tissue volumes in adult brain analyzed by 2-dimensional quantitative synthetic magnetic …

A Hagiwara, K Fujimoto, K Kamagata… - Investigative …, 2021 - journals.lww.com
Objectives Quantitative synthetic magnetic resonance imaging (MRI) enables the
determination of fundamental tissue properties, namely, T1 and T2 relaxation times and …

Age-related changes in tissue value properties in children: simultaneous quantification of relaxation times and proton density using synthetic magnetic resonance …

SM Lee, YH Choi, SK You, WK Lee, WH Kim… - Investigative …, 2018 - journals.lww.com
Objectives The properties of brain tissue undergo dynamic changes during maturation. T1
relaxation time (T1), T2 relaxation time (T2), and proton density (PD) are now simultaneously …

Myelination dictates axonal viscoelasticity

YC Chuang, A Alcantara, G Fabris… - European Journal of …, 2023 - Wiley Online Library
During development, dramatic changes in myelination, growth of neural networks and
changes in grey‐to‐white matter ratio build up the astonishingly plastic brain of a child. The …

Assessment of myelination in infants and young children by T1 relaxation time measurements using the magnetization-prepared 2 rapid acquisition gradient echoes …

F Kühne, WJ Neumann, P Hofmann, J Marques… - Pediatric …, 2021 - Springer
Background Axonal myelination is an important maturation process in the develo** brain.
Increasing myelin content correlates with the longitudinal relaxation rate (R1= 1/T1) in …

 Highly accelerated 3D MPRAGE using deep neural network–based reconstruction for brain imaging in children and young adults

W Jung, JY Kim, J Ko, G Jeong, HG Kim - European Radiology, 2022 - Springer
Objectives This study aimed to accelerate the 3D magnetization–prepared rapid gradient-
echo (MPRAGE) sequence for brain imaging through the deep neural network (DNN) …

Accelerated synthetic MRI with deep learning–based reconstruction for pediatric neuroimaging

E Kim, HH Cho, SH Cho, B Park… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Synthetic MR imaging is a time-efficient technique.
However, its rather long scan time can be challenging for children. This study aimed to …