LSD1: more than demethylation of histone lysine residues
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for map** the genomic location of …
seq) has become a valuable and widely used approach for map** the genomic location of …
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of
hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix …
hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix …
Most random gene expression signatures are significantly associated with breast cancer outcome
D Venet, JE Dumont, V Detours - PLoS computational biology, 2011 - journals.plos.org
Bridging the gap between animal or in vitro models and human disease is essential in
medical research. Researchers often suggest that a biological mechanism is relevant to …
medical research. Researchers often suggest that a biological mechanism is relevant to …
Vitamin A and retinoid signaling: genomic and nongenomic effects: thematic review series: fat-soluble vitamins: vitamin A
Z Al Tanoury, A Piskunov, C Rochette-Egly - Journal of lipid research, 2013 - ASBMB
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …
A user's guide to the encyclopedia of DNA elements (ENCODE)
ENCODE Project Consortium - PLoS biology, 2011 - journals.plos.org
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the
scientific and medical communities to interpret the human genome sequence and apply it to …
scientific and medical communities to interpret the human genome sequence and apply it to …
Retinoids, retinoic acid receptors, and cancer
Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
A user's guide to the encyclopedia of DNA elements (ENCODE)
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the
scientific and medical communities to interpret the human genome sequence and apply it to …
scientific and medical communities to interpret the human genome sequence and apply it to …
Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
SC Biddie, S John, PJ Sabo, RE Thurman, TA Johnson… - Molecular cell, 2011 - cell.com
Ligand-dependent transcription by the nuclear receptor glucocorticoid receptor (GR) is
mediated by interactions with coregulators. The role of these interactions in determining …
mediated by interactions with coregulators. The role of these interactions in determining …