Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Evolution of the human nervous system function, structure, and development

AMM Sousa, KA Meyer, G Santpere, FO Gulden… - Cell, 2017 - cell.com
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v. 14.0)

H Mi, A Muruganujan, X Huang, D Ebert, C Mills… - Nature protocols, 2019 - nature.com
The PANTHER classification system (http://www. pantherdb. org) is a comprehensive system
that combines genomes, gene function classifications, pathways and statistical analysis …

Adaptive sequence divergence forged new neurodevelopmental enhancers in humans

RJ Mangan, FC Alsina, F Mosti, JE Sotelo-Fonseca… - Cell, 2022 - cell.com
Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …

PANTHER version 10: expanded protein families and functions, and analysis tools

H Mi, S Poudel, A Muruganujan… - Nucleic acids …, 2016 - academic.oup.com
PANTHER (P rotein An alysis TH rough E volutionary R elationships, http://pantherdb. org) is
a widely used online resource for comprehensive protein evolutionary and functional …

Large-scale gene function analysis with the PANTHER classification system

H Mi, A Muruganujan, JT Casagrande, PD Thomas - Nature protocols, 2013 - nature.com
The PANTHER (protein annotation through evolutionary relationship) classification system
(http://www. pantherdb. org/) is a comprehensive system that combines gene function …

Cortical evolution: judge the brain by its cover

DH Geschwind, P Rakic - Neuron, 2013 - cell.com
To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

A genome-scan method to identify selected loci appropriate for both dominant and codominant markers: a Bayesian perspective

M Foll, O Gaggiotti - Genetics, 2008 - academic.oup.com
Identifying loci under natural selection from genomic surveys is of great interest in different
research areas. Commonly used methods to separate neutral effects from adaptive effects …

Insights into hominid evolution from the gorilla genome sequence

A Scally, JY Dutheil, LDW Hillier, GE Jordan… - Nature, 2012 - nature.com
Gorillas are humans' closest living relatives after chimpanzees, and are of comparable
importance for the study of human origins and evolution. Here we present the assembly and …

A map of recent positive selection in the human genome

BF Voight, S Kudaravalli, X Wen, JK Pritchard - PLoS biology, 2006 - journals.plos.org
The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan …