Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …
parallel with new antibiotics, leading to a major global public health crisis over time …
Surveying membrane landscapes: a new look at the bacterial cell surface
Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …
The translocation assembly module (TAM) catalyzes the assembly of bacterial outer membrane proteins in vitro
The t ranslocation and a ssembly m odule (TAM) has been proposed to play a crucial role in
the assembly of a small subset of outer membrane proteins (OMPs) in Proteobacteria based …
the assembly of a small subset of outer membrane proteins (OMPs) in Proteobacteria based …
The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …
POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties
A Mellouk, P Jaouen, LJ Ruel, M Lê, C Martini… - Proceedings of the …, 2024 - pnas.org
The outer membrane (OM) of gram-negative bacteria serves as a vital organelle that is
densely populated with OM proteins (OMPs) and plays pivotal roles in cellular functions and …
densely populated with OM proteins (OMPs) and plays pivotal roles in cellular functions and …
Redefining the bacterial Type I protein secretion system
FJ Hodges, LT Von Vergel, AF Cunningham… - Advances in Microbial …, 2023 - Elsevier
Type I secretion systems (T1SS) are versatile molecular machines for protein transport
across the Gram-negative cell envelope. The archetypal Type I system mediates secretion of …
across the Gram-negative cell envelope. The archetypal Type I system mediates secretion of …
The TAM, a Translocation and Assembly Module for protein assembly and potential conduit for phospholipid transfer
The assembly of β-barrel proteins into the bacterial outer membrane is an essential process
enabling the colonization of new environmental niches. The TAM was discovered as a …
enabling the colonization of new environmental niches. The TAM was discovered as a …
A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli
Since its discovery nearly 60 years ago, TolC has been associated with various cellular
functions in Escherichia coli, including the efflux of environmental stressors and virulence …
functions in Escherichia coli, including the efflux of environmental stressors and virulence …
[HTML][HTML] Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis
TolC is the outer membrane protein responsible for antibiotic efflux in E. coli. Compared to
other outer membrane proteins it has an unusual fold and has been shown to fold …
other outer membrane proteins it has an unusual fold and has been shown to fold …
In Vivo Disulfide-Bond Crosslinking to Study β-Barrel Membrane Protein Interactions, Dynamicity, and Folding Intermediates
MT Doyle - Transmembrane β-Barrel Proteins: Methods and …, 2024 - Springer
Membrane-embedded β-barrels are the major building blocks of the Gram-negative outer
membrane and are involved in antibiotic resistance, virulence, and the maintenance of …
membrane and are involved in antibiotic resistance, virulence, and the maintenance of …