MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Abstract miRNAs are typically repressing gene expression by binding to the 3'UTR, leading
to degradation of the mRNA. This process is dominated by the eight-base seed region of the …

Identifying molecular circuits that control adipose tissue macrophage (ATM) function is
necessary to understand how ATMs contribute to tissue homeostasis and obesity-induced …

A growing number of evidences from clinical and preclinical studies have shown that
dysregulation of microRNA (miRNA) function contributes to the progression of cancer and …

Rationale: Triple-negative breast cancer (TNBC), which has the highest recurrence rate and
shortest survival time of all breast cancers, is in urgent need of a risk assessment method to …

MicroRNAs (miRNAs) are small, yet profoundly influential, non-coding RNAs that base-pair
with mRNAs to induce RNA silencing. Although the basic principles of miRNA biogenesis …

Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of small RNAs, yet their
regulatory roles have not been well understood. Here we studied the molecular mechanisms …