Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: a comprehensive review

A Ismail, HA El-Mahdy, AI Abulsoud… - International Journal of …, 2023 - Elsevier
Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …

Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology

JC Chatham, J Zhang, AR Wende - Physiological reviews, 2021 - journals.physiology.org
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

MicroRNAs' role in the environment-related non-communicable diseases and link to multidrug resistance, regulation, or alteration

MM Mahmoud, EF Sanad, NM Hamdy - Environmental Science and …, 2021 - Springer
The discovery of microRNAs (miRNAs) 20 years ago has advocated a new era of “small
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …

Circular RNA as an epigenetic regulator in chronic liver diseases

X Zeng, X Yuan, Q Cai, C Tang, J Gao - Cells, 2021 - mdpi.com
Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed
continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably …

Therapeutic delivery of tumor suppressor miRNAs for breast cancer treatment

SS Shinde, S Ahmed, JA Malik, U Hani, A Khanam… - Biology, 2023 - mdpi.com
Simple Summary The most frequent cancer in women is breast cancer (BC), which presents
a significant risk to their good health. Over the past few decades, several factors have …

Gene expression networks in the Drosophila genetic reference panel

LJ Everett, W Huang, S Zhou, MA Carbone… - Genome …, 2020 - genome.cshlp.org
A major challenge in modern biology is to understand how naturally occurring variation in
DNA sequences affects complex organismal traits through networks of intermediate …

Noncoding RNAs in diabetic nephropathy: pathogenesis, biomarkers, and therapy

J Lv, Y Wu, Y Mai, S Bu - Journal of diabetes research, 2020 - Wiley Online Library
The correlation between diabetes and systematic well‐being on human life has long
established. As a common complication of diabetes, the prevalence of diabetic nephropathy …

Non-coding RNAs as biomarkers in liquid biopsies with a special emphasis on extracellular vesicles in urological malignancies

P Zeuschner, J Linxweiler, K Junker - Expert review of molecular …, 2020 - Taylor & Francis
ABSTRACT Introduction: Non-coding RNAs (ncRNAs) are important regulators of cellular
signaling in tumor-related processes. They can not only be detected in tumor tissues, but …

100 years of evolving gene–disease complexities and scientific debutants

S Zeeshan, R **ong, BT Liang… - Briefings in …, 2020 - academic.oup.com
It's been over 100 years since the wordgene'is around and progressively evolving in several
scientific directions. Time-to-time technological advancements have heavily revolutionized …

Use of stem cell extracellular vesicles as a “holistic” approach to CNS repair

H Branscome, S Paul, D Yin, N El-Hage… - Frontiers in Cell and …, 2020 - frontiersin.org
Neurodegeneration is a hallmark of many diseases and disorders of the central nervous
system (CNS). High levels of neuroinflammation are often associated with irreparable …