Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016‏ - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

A practical guide to environmental association analysis in landscape genomics

C Rellstab, F Gugerli, AJ Eckert, AM Hancock… - Molecular …, 2015‏ - Wiley Online Library
Landscape genomics is an emerging research field that aims to identify the environmental
factors that shape adaptive genetic variation and the gene variants that drive local …

Evolutionary genomics can improve prediction of species' responses to climate change

AM Waldvogel, B Feldmeyer, G Rolshausen… - Evolution …, 2020‏ - academic.oup.com
Global climate change (GCC) increasingly threatens biodiversity through the loss of species,
and the transformation of entire ecosystems. Many species are challenged by the pace of …

Comparing methods for detecting multilocus adaptation with multivariate genotype–environment associations

BR Forester, JR Lasky, HH Wagner… - Molecular …, 2018‏ - Wiley Online Library
Identifying adaptive loci can provide insight into the mechanisms underlying local
adaptation. Genotype–environment association (GEA) methods, which identify these loci …

The paradox of adaptive trait clines with nonclinal patterns in the underlying genes

KE Lotterhos - Proceedings of the National Academy of Sciences, 2023‏ - pnas.org
Multivariate climate change presents an urgent need to understand how species adapt to
complex environments. Population genetic theory predicts that loci under selection will form …

Reliable Detection of Loci Responsible for Local Adaptation: Inference of a Null Model through Trimming the Distribution of FST

MC Whitlock, KE Lotterhos - The American Naturalist, 2015‏ - journals.uchicago.edu
Loci responsible for local adaptation are likely to have more genetic differentiation among
populations than neutral loci. However, neutral loci can vary widely in their amount of …

LFMM 2: fast and accurate inference of gene-environment associations in genome-wide studies

K Caye, B Jumentier, J Lepeule… - Molecular biology and …, 2019‏ - academic.oup.com
Gene-environment association (GEA) studies are essential to understand the past and
ongoing adaptations of organisms to their environment, but those studies are complicated by …

Ecological genomics meets community‐level modelling of biodiversity: Map** the genomic landscape of current and future environmental adaptation

MC Fitzpatrick, SR Keller - Ecology letters, 2015‏ - Wiley Online Library
Local adaptation is a central feature of most species occupying spatially heterogeneous
environments, and may factor critically in responses to environmental change. However …

Genome-wide scan for adaptive divergence and association with population-specific covariates

M Gautier - Genetics, 2015‏ - academic.oup.com
In population genomics studies, accounting for the neutral covariance structure across
population allele frequencies is critical to improve the robustness of genome-wide scan …

Common garden experiments in the genomic era: new perspectives and opportunities

P de Villemereuil, OE Gaggiotti, M Mouterde… - Heredity, 2016‏ - nature.com
The study of local adaptation is rendered difficult by many evolutionary confounding
phenomena (for example, genetic drift and demographic history). When complex traits are …