Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease

LM Osborn, W Kamphuis, WJ Wadman, EM Hol - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …

Zinc finger proteins in neuro-related diseases progression

S Bu, Y Lv, Y Liu, S Qiao, H Wang - Frontiers in neuroscience, 2021 - frontiersin.org
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …

Biological roles of CCAAT/Enhancer-binding protein delta during inflammation

CY Ko, WC Chang, JM Wang - Journal of biomedical science, 2015 - Springer
CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding
protein family, and these proteins function as transcription factors in many biological …

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

M Pulido-Salgado, JM Vidal-Taboada, J Saura - Progress in Neurobiology, 2015 - Elsevier
CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …

Glial gene networks associated with alcohol dependence

EK Erickson, YA Blednov, RA Harris, RD Mayfield - Scientific reports, 2019 - nature.com
Chronic alcohol abuse alters the molecular structure and function of brain cells. Recent work
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …

Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice

J Lu, L Lu, Y Yu, J Baranowski, EC Claud - Scientific Reports, 2020 - nature.com
Neonatal morbidities are associated with long term neurological deficits in life and have also
been associated with dysbiosis. We tested whether optimizing the neonate's microbiome …

Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain

Q Yu, YZ Liu, YB Zhu, YY Wang, Q Li… - Brain Structure and …, 2019 - Springer
The D2 dopamine receptor (Drd2) is implicated in several brain disorders such as
schizophrenia, Parkinson's disease, and drug addiction. Drd2 is also the primary target of …

Exploring the causal pathway from telomere length to Alzheimer's disease: an update Mendelian randomization study

K Gao, C Wei, J Zhu, X Wang, G Chen, Y Luo… - Frontiers in …, 2019 - frontiersin.org
Increasing evidence shows that telomere length shortening is associated with the risk for
Alzheimer's disease (AD), pointing to a potential modifiable target for prevention. However …

Inhibition of the EGFR/STAT3/CEBPD axis reverses cisplatin cross-resistance with paclitaxel in the urothelial carcinoma of the urinary bladder

WJ Wang, CF Li, YY Chu, YH Wang, TC Hour… - Clinical Cancer …, 2017 - AACR
Purpose: Cisplatin (CDDP) is frequently used in combination chemotherapy with paclitaxel
for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has …