Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …
arise as the disease progresses. A growing body of evidence suggests that pathological …
Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease
LM Osborn, W Kamphuis, WJ Wadman, EM Hol - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …
decline in episodic memory followed by a more general decline in overall cognitive abilities …
Zinc finger proteins in neuro-related diseases progression
S Bu, Y Lv, Y Liu, S Qiao, H Wang - Frontiers in neuroscience, 2021 - frontiersin.org
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …
Biological roles of CCAAT/Enhancer-binding protein delta during inflammation
CY Ko, WC Chang, JM Wang - Journal of biomedical science, 2015 - Springer
CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding
protein family, and these proteins function as transcription factors in many biological …
protein family, and these proteins function as transcription factors in many biological …
C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS
CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …
basic-leucine zipper class which share phylogenetic, structural and functional features. In …
Glial gene networks associated with alcohol dependence
Chronic alcohol abuse alters the molecular structure and function of brain cells. Recent work
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice
Neonatal morbidities are associated with long term neurological deficits in life and have also
been associated with dysbiosis. We tested whether optimizing the neonate's microbiome …
been associated with dysbiosis. We tested whether optimizing the neonate's microbiome …
Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain
Q Yu, YZ Liu, YB Zhu, YY Wang, Q Li… - Brain Structure and …, 2019 - Springer
The D2 dopamine receptor (Drd2) is implicated in several brain disorders such as
schizophrenia, Parkinson's disease, and drug addiction. Drd2 is also the primary target of …
schizophrenia, Parkinson's disease, and drug addiction. Drd2 is also the primary target of …
Exploring the causal pathway from telomere length to Alzheimer's disease: an update Mendelian randomization study
K Gao, C Wei, J Zhu, X Wang, G Chen, Y Luo… - Frontiers in …, 2019 - frontiersin.org
Increasing evidence shows that telomere length shortening is associated with the risk for
Alzheimer's disease (AD), pointing to a potential modifiable target for prevention. However …
Alzheimer's disease (AD), pointing to a potential modifiable target for prevention. However …
Inhibition of the EGFR/STAT3/CEBPD axis reverses cisplatin cross-resistance with paclitaxel in the urothelial carcinoma of the urinary bladder
Purpose: Cisplatin (CDDP) is frequently used in combination chemotherapy with paclitaxel
for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has …
for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has …