Build to understand: synthetic approaches to biology
In this review we discuss how synthetic biology facilitates the task of investigating genetic
circuits that are observed in naturally occurring biological systems. Specifically, we give …
circuits that are observed in naturally occurring biological systems. Specifically, we give …
Exit from quiescence displays a memory of cell growth and division
Reactivating quiescent cells to proliferate is critical to tissue repair and homoeostasis.
Quiescence exit is highly noisy even for genetically identical cells under the same …
Quiescence exit is highly noisy even for genetically identical cells under the same …
Network motifs modulate druggability of cellular targets
Druggability refers to the capacity of a cellular target to be modulated by a small-molecule
drug. To date, druggability is mainly studied by focusing on direct binding interactions …
drug. To date, druggability is mainly studied by focusing on direct binding interactions …
Study Quiescence Heterogeneity by Coupling Single-Cell Measurements and Computer Modeling
JS Kwon, X Wang, G Yao - Cellular Quiescence: Methods and Protocols, 2018 - Springer
Single-cell measurements combined with mathematical modeling and computer simulations
are powerful tools for understanding and exploring dynamical behaviors of gene networks …
are powerful tools for understanding and exploring dynamical behaviors of gene networks …