The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a
wealth of biological processes, including ciliary beating, cell division and intracellular …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at
appropriate velocities in membranous organelles and protein complexes. Intracellular …

Many intracellular compartments, including MHC class II-containing lysosomes [1],
melanosomes [2], and phagosomes [3], move along microtubules in a bidirectional manner …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Many cellular processes require large forces that are generated collectively by multiple
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …

Intracellular transport is based on molecular motors that pull cargos along cytoskeletal
filaments. One motor species always moves in one direction, eg, conventional kinesin …

Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the
microbicidal properties required for the innate immune response. Here we demonstrate that …