Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Genetics of multiple sclerosis: lessons from polygenicity

A Goris, M Vandebergh, JL McCauley… - The Lancet …, 2022 - thelancet.com
Large-scale map** studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Vitamin D and human health: evidence from Mendelian randomization studies

A Fang, Y Zhao, P Yang, X Zhang… - European journal of …, 2024 - Springer
We summarized the current evidence on vitamin D and major health outcomes from
Mendelian randomization (MR) studies. PubMed and Embase were searched for original …

Health effects of vitamin D supplementation: lessons learned from randomized controlled trials and mendelian randomization studies

R Bouillon, MS LeBoff, RE Neale - Journal of Bone and Mineral …, 2023 - academic.oup.com
Vitamin D plays an important role in calcium homeostasis and many cellular processes.
Although vitamin D supplements are widely recommended for community‐dwelling adults …

Mendelian randomization as a tool to gain insights into the mosaic causes of autoimmune diseases

C Chen, P Wang, RD Zhang, Y Fang, LQ Jiang… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (ADs) are a broad range of disorders which are characterized by long-
term inflammation and tissue damage arising from an immune response against one's own …

The role of gut microbiome in the pathogenesis of multiple sclerosis and related disorders

A Dunalska, K Saramak, N Szejko - Cells, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic, progressive neuroinflammatory disease with a complex
pathophysiological background. A variety of diverse factors have been attributed to the …

Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study

D Sun, R Wang, Q Du, Y Zhang, H Chen, Z Shi… - Journal of translational …, 2024 - Springer
Background Observational studies have suggested an association between multiple
sclerosis (MS) and cortical structure, but the results have been inconsistent. Objective We …

Effects of vitamin D and body mass index on disease risk and relapse hazard in multiple sclerosis: a mendelian randomization study

M Vandebergh, B Dubois, A Goris - Neurology: Neuroimmunology & …, 2022 - neurology.org
Background and Objectives Decreased vitamin D levels and obesity are associated with an
increased risk for multiple sclerosis (MS). However, whether they also affect the disease …

Mendelian randomization as a tool for causal inference in human nutrition and metabolism

SC Larsson - Current opinion in lipidology, 2021 - journals.lww.com
Mendelian randomization can be used as a tool to improve causal inference in
observational studies assessing the role of nutritional factors and metabolites in health and …