The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …

Surviving a given infection requires the generation of a controlled immune response. Failure
to establish or restore homeostatic conditions during or following the onset of an infection …

Each microenvironment requires a specific set of regulatory elements that are finely and
constantly tuned to maintain local homeostasis. Various populations of regulatory T cells …

Although Bacillus Calmette-Guérin (BCG) is the most successful immunotherapy for high-
risk non-muscle-invasive bladder cancer, approximately 30% of patients are unresponsive …

Host genetic and environmental factors including age, biological sex, diet, geographical
location, microbiome composition and metabolites converge to influence innate and …

In the last century, we have seen a dramatic rise in the number of older persons globally, a
trend known as the grey (or silver) tsunami. People live markedly longer than their …

Protection against liver-stage malaria relies on the induction of high frequencies of antigen-
specific CD8+ T cells. We have previously reported high protective levels against mouse …

Failure to establish an appropriate balance between pro-and anti-inflammatory immune
responses is believed to contribute to pathogenesis of severe malaria. To determine …

The population dynamics that enable a small number of regulatory T (TR) cells to control the
immune responses to foreign Ags by the much larger conventional T cell subset were …

This review discusses situations when the magnitude and function of immune responses to
virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ …