Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview

ID Da Silva, V Wuidar, M Zielonka, C Pequeux - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The endometrium is crucial for the perpetuation of human species. It is a complex and
dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based …

Uterine luminal epithelium as the transient gateway for embryo implantation

X Ye - Trends in Endocrinology & Metabolism, 2020 - cell.com
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo.
Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural …

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

L Spiga, RT Fansler, YR Perera, NG Shealy… - Cell Host & Microbe, 2023 - cell.com
During intestinal inflammation, host nutritional immunity starves microbes of essential
micronutrients, such as iron. Pathogens scavenge iron using siderophores, including …

[HTML][HTML] Mouse oocytes develop in cysts with the help of nurse cells

W Niu, AC Spradling - Cell, 2022 - cell.com
Mouse germline cysts, on average, develop into six oocytes supported by 24 nurse cells that
transfer cytoplasm and organelles to generate a Balbiani body. We showed that between …

Embryo-derive TNF promotes decidualization via fibroblast activation

ST Chen, WW Shi, YQ Lin, ZS Yang, Y Wang, MY Li… - Elife, 2023 - elifesciences.org
Decidualization is a process in which endometrial stromal fibroblasts differentiate into
specialized secretory decidual cells and essential for the successful establishment of …

METTL3-dependent m6A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling

S Wan, Y Sun, J Zong, W Meng, J Yan, K Chen… - Cell Death & …, 2023 - nature.com
Infertility is a worldwide reproductive health problem and there are still many unknown
etiologies of infertility. In recent years, increasing evidence emerged and confirmed that …

Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua

VC Cheung, CY Peng, M Marinić, NJ Sakabe, I Aneas… - Cell Reports, 2021 - cell.com
Various human diseases and pregnancy-related disorders reflect endometrial dysfunction.
However, rodent models do not share fundamental biological processes with the human …

TGFβ superfamily signaling and uterine decidualization

N Ni, Q Li - Reproductive biology and endocrinology, 2017 - Springer
Decidualization is an intricate biological process where extensive morphological, functional,
and genetic changes take place in endometrial stromal cells to support the development of …

[HTML][HTML] Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization

M Zhou, H Xu, D Zhang, C Si, X Zhou, H Zhao… - Journal of Advanced …, 2021 - Elsevier
Introduction Recurrent implantation failure (RIF) is a challenging problem of assisted
reproductive technology that arises mainly due to inadequate endometrial receptivity and its …

Investigation of infertility using endometrial organoids

K Nikolakopoulou, MY Turco - Reproduction, 2021 - rep.bioscientifica.com
Infertility is a common problem in modern societies with significant socio-psychological
implications for women. Therapeutic interventions are often needed which, depending on …