Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each
cell type has a unique 3D genome organization that determines its cell identity. An …

Glioblastoma (GBM) is a devastating human malignancy. GBM stem-like cells (GSCs) drive
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …

Extrachromosomal, circular DNA (ecDNA) is emerging as a prevalent yet less characterized
oncogenic alteration in cancer genomes. We leverage ChIA-PET and ChIA-Drop chromatin …

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has
become widely known because of its functional relevance for stem cells. In the develo** …

Background Although spatial organization of compartments and topologically associating
domains at large scale is relatively well studied, the spatial organization of regulatory …

Background: Transcriptional reconfiguration is central to heart failure, the most common
cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin …

SOX2 is a transcription factor conserved throughout vertebrate evolution, whose expression
marks the central nervous system from the earliest developmental stages. In humans, SOX2 …

Enhancer reprogramming has been proposed as a key source of transcriptional
dysregulation during tumorigenesis, but the molecular mechanisms underlying this process …