Protein tyrosine phosphatase 1B (PTP1B): A comprehensive review of its role in pathogenesis of human diseases
D Kołodziej-Sobczak, Ł Sobczak… - International Journal of …, 2024 - mdpi.com
Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways
and results in numerous human diseases. In particular, its involvement has been well …
and results in numerous human diseases. In particular, its involvement has been well …
Significance of TRAIL/Apo-2 ligand and its death receptors in apoptosis and necroptosis signalling: Implications for cancer-targeted therapeutics
The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …
Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships
Free fatty acid receptor 1 (FFAR1 or GPR40) is a potential target for treating type 2 diabetes
mellitus (T2DM) and related disorders that have been extensively researched for many …
mellitus (T2DM) and related disorders that have been extensively researched for many …
Chalcone-Monoterpene Derivatives from the Buds of Cleistocalyx operculatus and Their Potential as Protein Tyrosine Phosphatase 1B Inhibitors
Four new compounds, racemic chalcone-monoterpene hybrids (1–3) and a chalcone (9),
along with nine known compounds (4–8, 10–13), have been isolated from the buds of …
along with nine known compounds (4–8, 10–13), have been isolated from the buds of …
Exploring the therapeutic potentials of cuminaldehyde: a comprehensive review of biological activities, mechanisms, and novel delivery systems
Cuminaldehyde (CUM) is a bioactive compound majorly present in the seeds of Cuminum
cyminum. The plant C. cyminum is the hub of numerous bioactive compounds that have …
cyminum. The plant C. cyminum is the hub of numerous bioactive compounds that have …
Spectroscopic investigations, quantum chemical, molecular docking and drug likeness studies of t-butyl-3, 4, 5-trimethyl-2-pyrrole carboxylate
The geometrical structure of t‑butyl‑3, 4, 5-trimethyl-2-pyrrole carboxylate (TBTPC) was
computed by DFT calculations using the B3LYP method and the 6–311++ G (d, p) basis set …
computed by DFT calculations using the B3LYP method and the 6–311++ G (d, p) basis set …
Chemo-profiling and exploring therapeutic potential of Momordica dioica Roxb. ex Willd. for managing metabolic related disorders: In-vitro studies, and docking based …
Abstract Ethnopharmacological relevance Momordica dioica Roxb. ex Willd.(M. dioica
Roxb.) a nutritious and therapeutic property rich crop of Cucurbitaceae plant family. In …
Roxb.) a nutritious and therapeutic property rich crop of Cucurbitaceae plant family. In …
Theoretical study on the design of allosteric inhibitors of diabetes associated protein PTP1B
J Zhan, Z Liu, H Gao - Frontiers in Pharmacology, 2024 - frontiersin.org
The protein tyrosine phosphatase 1B (PTP1B) is a critical therapeutic target for type 2
diabetes mellitus (T2DM). Many PTP1B inhibitors have been reported, however, most of …
diabetes mellitus (T2DM). Many PTP1B inhibitors have been reported, however, most of …
Synthesis, single crystal XRD, in vitro evaluation, molecular docking and ADMET studies of cuminaldehyde-thiazolidine-2, 4-dione hybrids as potential α-glucosidase …
In order to find effective α-glucosidase inhibitors, a series of cuminaldehyde-TZD hybrids
were designed, synthesized and evaluated for their α-glucosidase inhibitory activity by using …
were designed, synthesized and evaluated for their α-glucosidase inhibitory activity by using …
Monotherapy or combination therapy of Oleanolic acid? From therapeutic significance and drug delivery to clinical studies: A comprehensive review
Oleanolic acid (OA) is a pentacyclic triterpenoid molecule widely distributed throughout
medicinal plants. This naturally occurring OA has attracted considerable interest due to its …
medicinal plants. This naturally occurring OA has attracted considerable interest due to its …