Reciprocal regulation of mesenchymal stem cells and immune responses
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
Haematopoietic stem cell activity and interactions with the niche
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
[HTML][HTML] Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
R Bogeska, AM Mikecin, P Kaschutnig, M Fawaz… - Cell stem cell, 2022 - cell.com
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …
following injury, such as following infection or inflammation. These challenges impair HSC …
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization
The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …
regeneration. However, its cellular and spatial organization remains controversial. Here, we …
Bone marrow niches in haematological malignancies
Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …
Physiological signaling functions of reactive oxygen species in stem cells: from flies to man
SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
The endothelium–bone axis in development, homeostasis and bone and joint disease
J Tuckermann, RH Adams - Nature Reviews Rheumatology, 2021 - nature.com
Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …
processes such as tissue oxygenation, metabolism and immune surveillance. The …
The mesenchymal context in inflammation, immunity and cancer
Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …