The epidermal growth factor network: role in oocyte growth, maturation and developmental competence

D Richani, RB Gilchrist - Human reproduction update, 2018 - academic.oup.com
BACKGROUND The LH surge induces great physiological changes within the preovulatory
follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting …

Oocyte maturation and quality: role of cyclic nucleotides

RB Gilchrist, AM Luciano, D Richani, HT Zeng… - …, 2016 - rep.bioscientifica.com
The develo** fetus requires substantial amounts of fatty acids to support rapid cellular
growth and activity. Although the fatty acid composition delivered to the fetus is largely …

An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances oocyte competence and embryo yield

F Sánchez, F Lolicato, S Romero, M De Vos… - Human …, 2017 - academic.oup.com
STUDY QUESTION Are meiotic and developmental competence of human oocytes from
small (2–8 mm) antral follicles improved by applying an optimized IVM method involving a …

In vitro maturation as an alternative to standard in vitro fertilization for patients diagnosed with polycystic ovaries: a comparative analysis of fresh, frozen and …

ML Walls, T Hunter, JP Ryan, JA Keelan… - Human …, 2015 - academic.oup.com
STUDY QUESTION Is in vitro maturation (IVM) as successful as standard in vitro fertilization
(IVF) for the treatment of patients with polycystic ovaries (PCO) in terms of fresh, frozen and …

Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles

F Sanchez, AH Le, VNA Ho, S Romero… - Journal of assisted …, 2019 - Springer
Purpose To investigate the effectiveness of a biphasic IVM culture strategy at improving IVM
outcomes in oocytes from small follicles (< 6 mm) compared with routine Standard IVM in …

A fresh start for IVM: capacitating the oocyte for development using pre-IVM

RB Gilchrist, TM Ho, M De Vos… - Human …, 2024 - academic.oup.com
BACKGROUND While oocyte IVM is practiced sporadically it has not achieved widespread
clinical practice globally. However, recently there have been some seminal advances in our …

Epigenetic dynamics during preimplantation development

C Marcho, W Cui, J Mager - Reproduction, 2015 - rep.bioscientifica.com
In vitro maturation (IVM) offers significant benefits for human infertility treatment and animal
breeding, but this potential is yet to be fully realised due to reduced oocyte developmental …

Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions

HJ Li, ML Sutton-McDowall, X Wang… - Human …, 2016 - academic.oup.com
STUDY QUESTION Can bovine oocyte antioxidant defence and oocyte quality be improved
by extending the duration of pre-in vitro maturation (IVM) with cyclic adenosine mono …

Human cumulus-enclosed germinal vesicle oocytes from early antral follicles reveal heterogeneous cellular and molecular features associated with in vitro maturation …

F Sánchez, S Romero, M De Vos… - Human …, 2015 - academic.oup.com
STUDY QUESTION Are oocyte size, chromatin remodelling, transcriptional activity and
mitochondrial distribution in human immature oocytes from early antral follicles retrieved for …

Prematuration with cyclic adenosine monophosphate modulators alters cumulus cell and oocyte metabolism and enhances developmental competence of in vitro …

HT Zeng, D Richani, ML Sutton-McDowall… - Biology of …, 2014 - academic.oup.com
Oocyte in vitro maturation (IVM) is an important assisted reproductive technology and
research tool. The adoption of IVM into routine clinical practice has been hindered by its …