Multitask multilayer-prediction model for predicting mechanical ventilation and the associated mortality rate

N El-Rashidy, Z Tarek, AM Elshewey… - Neural Computing and …, 2025 - Springer
Mechanical ventilation (MV) is a crucial intervention in the intensive care unit (ICU) for
severely ill patients. However, it can potentially contribute to lung damage due to the …

Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs

MS Stroe, L De Clerck, M Dhaenens… - Basic & Clinical …, 2024 - Wiley Online Library
Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and
mortality. As perinatal asphyxia and TH impact neonatal physiology, this could also …

Multi-tissue transcriptional changes and core circadian clock disruption following intensive care

HC Hollis, JN Francis, RC Anafi - Frontiers in Physiology, 2022 - frontiersin.org
Objective: Both critical illness and current care have been hypothesized to upset daily
rhythms and impair molecular circadian function. However, the influence of critical illness on …

Whole-body positive synchronization pattern of metabolic transcriptomes

EZ Sussman, D Mor, J Somekh - bioRxiv, 2023 - biorxiv.org
Understanding the relationship between transcriptomes in the entire body is crucial for
comprehending health and disease. To achieve this, we have developed a framework that …

Whole-Body Coordination of Metabolic Genomic Co-Expression Networks

EZ Sussman - 2023 - search.proquest.com
Several internal biological mechanisms induce the human body's organs to preserve
homeostasis while external factors perturb it. These internal mechanisms include circadian …

Applying Machine Learning Algorithms To Forecast MV Effects On Human Tissue Transcriptomes

A Moore, S Agarwal, C Thompson - osf.io
Mechanical ventilation (MV) is a life-saving treatment for individuals suffering from
respiratory insufficiency. Nonetheless, MV is linked to a slew of problems and an increased …