Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …

We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …

The majority of oncogenic drivers are intracellular proteins, constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …

The majority of oncogenic drivers are intracellular proteins, thus constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …

Microscaled proteogenomics was deployed to probe the molecular basis for differential
response to neoadjuvant carboplatin and docetaxel combination chemotherapy for triple …

Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options,
and many of these patients die of their disease. B7-H3 is an immune checkpoint protein …

A small fraction of cancer patients with advanced disease survive significantly longer than
patients with clinically comparable tumors. Molecular mechanisms for exceptional …

Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve
therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive pediatric solid …

Neuroblastoma is a childhood cancer with heterogeneous clinical outcomes. To
comprehensively assess the impact of telomere maintenance mechanism (TMM) on clinical …