Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by
integral membrane synthases. The repeating sequence is perfectly homogeneous, and is …

Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix
(ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be …

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Abstract Proteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage
and line the synovial joint. Lubricin may play a role in modulating inflammatory responses …

When lubricated by synovial fluid, articular cartilage provides some of the lowest friction
coefficients found in nature. While it is known that macromolecular constituents of synovial …

Background One potential mechanism for early superficial cartilage wear in normal joints is
alteration of the lubricant content and quality of synovial fluid. The purpose of this study was …

Osteoarthritis (OA) is the most common joint disease, characterized by progressive
destruction of the articular cartilage. The surface of joint cartilage is the first defensive and …

Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …

Damage to cartilage represents one of the most challenging tasks of musculoskeletal
therapeutics due to its limited propensity for healing and regenerative capabilities. Lack of …

Objectives We hypothesized that high-molecular-weight (MW) cross-linked (CL) hyaluronic
acid (HA) improves joint lubrication and has an enhanced chondroprotective effect. We …