Macromolecular drug carriers for targeted glioblastoma therapy: Preclinical studies, challenges, and future perspectives

D Raucher, S Dragojevic, J Ryu - Frontiers in oncology, 2018 - frontiersin.org
Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable
cancers—owing to its strong tendency for intracranial dissemination, high proliferation …

Connexins and pannexins: Important players in tumorigenesis, metastasis and potential therapeutics

SV Graham, JX Jiang, M Mesnil - International journal of molecular …, 2018 - mdpi.com
Since their characterization more than five decades ago, gap junctions and their structural
proteins—the connexins—have been associated with cancer cell growth. During that period …

Dual contrast-magnetic resonance fingerprinting (DC-MRF): a platform for simultaneous quantification of multiple MRI contrast agents

CE Anderson, SB Donnola, Y Jiang, J Batesole… - Scientific reports, 2017 - nature.com
Abstract Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely
used to provide critical assessments of disease for both clinical and basic science imaging …

Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics

Z Wu, L Dai, K Tang, Y Ma, B Song… - Regenerative …, 2021 - academic.oup.com
Glioblastoma (GBM) is the most aggressive malignant brain tumour, with a median survival
of 3 months without treatment and 15 months with treatment. Early GBM diagnosis can …

Peptide‐based building blocks as structural elements for supramolecular Gd‐containing MRI contrast agents

C Diaferia, E Gianolio, A Accardo - Journal of Peptide Science, 2019 - Wiley Online Library
Magnetic resonance imaging (MRI) is one of the most important clinic diagnostic tool used to
obtain high‐quality body images. The administration of low‐molecular‐weight Gd complex …

Complex role of connexin 43 in astrocytic tumors and possible promotion of glioma-associated epileptic discharge

H Dong, XW Zhou, X Wang… - Molecular …, 2017 - spandidos-publications.com
Connexin (Cx) 43 is a multifunction protein which forms gap junction channels and hemi-
channels. It also contains abundant binding domains which possess the ability to interact …

Localized Increased Permeability of Blood–Brain Barrier for Antibody Conjugates in the Cuprizone Model of Demyelination

T Abakumova, A Kuzkina, P Koshkin… - International Journal of …, 2023 - mdpi.com
The development of new neurotherapeutics depends on appropriate animal models being
chosen in preclinical studies. The cuprizone model is an effective tool for studying …

Current concepts and perspectives on connexin43: a mini review

Q Zhang, X Bai, Y Liu, K Wang… - Current Protein and …, 2018 - ingentaconnect.com
Connexins are a family of gap junction proteins widely distributed in human organs and
tissues. Gap junctions are organized systems of intercellular protein channels that allow the …

Simultaneous quantification of SPIO and gadolinium contrast agents using MR fingerprinting

A Marriott, C Bowen, J Rioux, K Brewer - Magnetic resonance imaging, 2021 - Elsevier
Purpose Develop a magnetic resonance fingerprinting (MRF) methodology with R 2∗
quantification, intended for use with simultaneous contrast agent concentration map** …

Ultrahigh field magnetic resonance imaging: new frontiers and possibilities in human imaging

MA Zubkov, AE Andreychenko, EI Kretov… - Physics …, 2019 - iopscience.iop.org
Increasing the strength of the static magnetic field is the main trend in modern magnetic
resonance imaging (MRI) of humans. Performing MRI in ultrahigh fields (7 T or more) …