Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
Covering: up to 2013 Although holo-acyl carrier protein synthase, AcpS, a
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …
Burkholderia: an update on taxonomy and biotechnological potential as antibiotic producers
Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over
80 species have been formally named and multiple other genotypic groups likely represent …
80 species have been formally named and multiple other genotypic groups likely represent …
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
Functional analysis of genome sequences requires methods for cloning DNA of interest.
However, existing methods, such as library cloning and screening, are too demanding or …
However, existing methods, such as library cloning and screening, are too demanding or …
Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds
CT Walsh, RV O'Brien, C Khosla - … Chemie International Edition, 2013 - Wiley Online Library
Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …
Genomics of secondary metabolite production by Pseudomonas spp.
Covering: up to June 2009 Pseudomonas is a diverse genus of Gammaproteobacteria with
more than 60 species exhibiting varied life styles in a wide range of environments, including …
more than 60 species exhibiting varied life styles in a wide range of environments, including …
Metabolites from symbiotic bacteria
J Piel - Natural product reports, 2009 - pubs.rsc.org
Metabolites from symbiotic bacteria - Natural Product Reports (RSC Publishing) DOI:10.1039/B703499G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …
Biosynthetic pathways to nonproteinogenic α-amino acids
JB Hedges, KS Ryan - Chemical reviews, 2019 - ACS Publications
Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …
Burkholderia as a Source of Natural Products
S Kunakom, AS Eustáquio - Journal of natural products, 2019 - ACS Publications
Burkholderia bacteria are multifaceted organisms that are ecologically and metabolically
diverse. The Burkholderia genus has gained prominence because it includes human …
diverse. The Burkholderia genus has gained prominence because it includes human …
Engineered and artificial metalloenzymes for selective C–H functionalization
X Ren, R Fasan - Current opinion in green and sustainable chemistry, 2021 - Elsevier
The direct functionalization of C–H bonds constitutes a powerful strategy to construct and
diversify organic molecules. However, controlling the chemo-and site-selectivity of this …
diversify organic molecules. However, controlling the chemo-and site-selectivity of this …