Preeclampsia: pathophysiology, challenges, and perspectives
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …
Pre-eclampsia: pathogenesis, novel diagnostics and therapies
EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
Vascular dysfunction in preeclampsia
MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …
Neurodevelopmental outcomes of prenatal preeclampsia exposure
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …
negative child health outcomes. Here, we review epidemiological and basic neuroscience …
Rodent models of hypertension
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …
disease. As a multifactorial and systemic disease that involves multiple organs and systems …
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum
Maternal mortality rates are at an all-time high across the world and are set to increase in
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …
Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents
Cardiovascular disease represents the leading cause of death in the United States, and
metabolic diseases such as obesity represent the primary impediment to improving …
metabolic diseases such as obesity represent the primary impediment to improving …
Antidiuretic hormone and serum osmolarity physiology and related outcomes: what is old, what is new, and what is unknown?
Context Although the physiology of sodium, water, and arginine vasopressin (AVP), also
known as antidiuretic hormone, has long been known, accumulating data suggest that this …
known as antidiuretic hormone, has long been known, accumulating data suggest that this …
Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling
MA Opichka, MC Livergood, K Balapattabi… - Science …, 2023 - science.org
Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its
molecular causes and consequences remain largely undefined. Multiple hormones …
molecular causes and consequences remain largely undefined. Multiple hormones …
Introduction to a Compendium on the Pathophysiology and Treatment of Hypertension
G Mancia, JE Hall - Circulation Research, 2019 - ahajournals.org
968 Circulation Research March 29, 2019 hypertension and lead to more precise therapies,
as well as reduced morbidity and mortality. Finally, Mancia et al12 review the evidence that …
as well as reduced morbidity and mortality. Finally, Mancia et al12 review the evidence that …