Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

Exosomes and exosome-inspired vesicles for targeted drug delivery

SG Antimisiaris, S Mourtas, A Marazioti - Pharmaceutics, 2018 - mdpi.com
The similarities between exosomes and liposomes, together with the high organotropism of
several types of exosomes, have recently prompted the development of engineered …

Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

[HTML][HTML] M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124

Y Song, Z Li, T He, M Qu, L Jiang, W Li, X Shi, J Pan… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Microglia play a critical role in modulating cell death and neurobehavioral
recovery in response to brain injury either by direct cell-cell interaction or indirect secretion …

Mesenchymal stem cells-derived exosomes for drug delivery

Y Sun, G Liu, K Zhang, Q Cao, T Liu, J Li - Stem cell research & therapy, 2021 - Springer
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid
bilayers without organelles. In recent years, an increasing number of researchers have …

Exosomes: the next generation of endogenous nanomaterials for advanced drug delivery and therapy

W Liao, Y Du, C Zhang, F Pan, Y Yao, T Zhang, Q Peng - Acta biomaterialia, 2019 - Elsevier
Abstract Development of functional nanomaterials is of great importance and significance for
advanced drug delivery and therapy. Nevertheless, exogenous nanomaterials have a great …

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

E Lázaro-Ibáñez, FN Faruqu, AF Saleh, AM Silva… - ACS …, 2021 - ACS Publications
The ability to track extracellular vesicles (EVs) in vivo without influencing their biodistribution
is a key requirement for their successful development as drug delivery vehicles and …

Imaging extracellular vesicles: current and emerging methods

STY Chuo, JCY Chien, CPK Lai - Journal of biomedical science, 2018 - Springer
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They
range from 30 nm to several micrometers in diameter, and ferry biological cargos such as …

Extracellular vesicles in angiogenesis

D Todorova, S Simoncini, R Lacroix, F Sabatier… - Circulation …, 2017 - Am Heart Assoc
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies,
microvesicles, and exosomes, have emerged as important players in cell-to-cell …

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

D Yuan, Y Zhao, WA Banks, KM Bullock, M Haney… - Biomaterials, 2017 - Elsevier
Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of
small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the …