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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
[HTML][HTML] How computational models can help unlock biological systems
With computation models playing an ever increasing role in the advancement of science, it is
important that researchers understand what it means to model something; recognize the …
important that researchers understand what it means to model something; recognize the …
Active vertex model for cell-resolution description of epithelial tissue mechanics
We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of
confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail …
confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail …
Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results
In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …
Nonlinear modelling of cancer: bridging the gap between cells and tumours
Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …
cure for cancer remains elusive. The disease initiation is complex, and including initiation …
Multiscale cancer modeling
Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
The roots of bioinformatics in theoretical biology
From the late 1980s onward, the term “bioinformatics” mostly has been used to refer to
computational methods for comparative analysis of genome data. However, the term was …
computational methods for comparative analysis of genome data. However, the term was …
Physical models of collective cell motility: from cell to tissue
In this article, we review physics-based models of collective cell motility. We discuss a range
of techniques at different scales, ranging from models that represent cells as simple self …
of techniques at different scales, ranging from models that represent cells as simple self …
Measuring forces and stresses in situ in living tissues
Development, homeostasis and regeneration of tissues result from a complex combination
of genetics and mechanics, and progresses in the former have been quicker than in the …
of genetics and mechanics, and progresses in the former have been quicker than in the …
[کتاب][B] Mathematical modeling of biological pattern formation
A Deutsch, S Dormann, A Deutsch, S Dormann - 2017 - Springer
The application of mathematical models to explain the dynamics of biological pattern
formation started with the work of D'Arcy Thompson who showed that mathematics cannot …
formation started with the work of D'Arcy Thompson who showed that mathematics cannot …