Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

In humans, the glutathione S-transferases (GST) protein family is composed of seven
members that present remarkable structural similarity and some degree of overlap** …

The development of a controllable reactive nitrogen species (RNS) generation system for
cancer treatment has remained elusive. Herein, a supramolecular prodrug nanoassemblies …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential
roles in regulating biological events. Their aberrant behaviors are mostly associated with …

Metabolic disorders and abnormal immune function changes occur in tumor tissues and
cells to varying degrees. There is increasing evidence that reprogrammed energy …

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen
species (RNS), are generated in the body by various endogenous and exogenous systems …

Cardiovascular disease (CVD) is a broad term that incorporated a group of conditions that
affect the blood vessels and the heart. CVD is a foremost cause of fatalities around the …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor
microenvironment (TME) for esca** from immunosurveillance. Therefore, interrupting the …