Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Fibroblasts have a considerable functional and molecular heterogeneity and can play
various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Biobanks play an increasing role in contemporary research projects. These units meet all
requirements to regard them as a one of the most innovative and up-to-date in the field of …

N 6-methyladenosine (m6A) RNA modification maintained by N6-methyltransferases and
demethylases is involved in multiple biological functions. Methyltransferase like 3 (METTL3) …

Abstract Background Circular RNAs (circRNAs) have caught increasing attentions and
interests for their important involvement in cancer initiation and progression. This study aims …

Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer
(sCRC) patients. Genomic abnormalities which are potentially characteristic of such …

Suppressors of cytokine signalling (SOCS) proteins are modulators of cytokine and growth
factor signalling whose aberrant regulation has been linked to a variety of inflammatory and …

STAT3 is the most ubiquitous member of the STAT family and involved in many biological
processes, such as cell proliferation, differentiation, and apoptosis. Mounting evidence has …