Background Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One
of the main challenges in the management of OC is the late clinical presentation of disease …

Liquid biopsies hold the potential to inform cancer patient prognosis and to guide treatment
decisions at the time when direct tumor biopsy may be impractical due to its invasive nature …

The detection of rare circulating tumor cells (CTCs) in the blood of cancer patients has the
potential to be a powerful and noninvasive method for examining metastasis, evaluating …

The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …

Introduction: Despite advances in surgery and chemotherapy for ovarian cancer, 70% of
women still succumb to the disease. Biomarkers have contributed to the management of …

Ovarian cancer still remains the most lethal female cancer, since in most cases it is
diagnosed at an advanced stage. Usually after completion of primary treatment …

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and
metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular …

Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout
the human lifespan. In addition to contributing to the development of various tissues within …

Tumor-associated macrophages (TAMs) that appear in every stage of cancer progression
are usually tumor-promoting cells and are present abundantly in the tumor-associated …