Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

DY Shu, FJ Lovicu - Progress in retinal and eye research, 2017 - Elsevier
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

The airway epithelium: structural and functional properties in health and disease

DA Knight, ST Holgate - Respirology, 2003 - Wiley Online Library
The major function of the respiratory epithelium was once thought to be that of a physical
barrier. However, it constitutes the interface between the internal milieu and the external …

Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases

N Di Girolamo, J Chui, MT Coroneo… - Progress in retinal and …, 2004 - Elsevier
Pterygium is a common ocular surface disease apparently only observed in humans.
Chronic UV exposure is a widely accepted aetiological factor in the pathogenesis of this …

Identification and characterization of limbal stem cells

U Schlötzer-Schrehardt, FE Kruse - Experimental eye research, 2005 - Elsevier
The maintenance of a healthy corneal epithelium under both normal and wound healing
conditions is achieved by a population of stem cells (SC) located in the basal epithelium at …

TGF-β superfamily signaling in the eye: implications for ocular pathologies

S Hachana, B Larrivée - Cells, 2022 - mdpi.com
The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy

MV Netto, RR Mohan, R Ambrósio Jr, AEK Hutcheon… - Cornea, 2005 - journals.lww.com
Purpose: The corneal wound healing response is of particular relevance for refractive
surgical procedures since it is a major determinant of efficacy and safety. The purpose of this …

TGFβ pathobiology in the eye

S Saika - Laboratory investigation, 2006 - nature.com
Transforming growth factor β (TGFβ), a multifunctional growth factor, is one of the most
important ligands involved in the regulation of cell behavior in ocular tissues in physiological …

A histological and immunohistochemical study of the subsynovial connective tissue in idiopathic carpal tunnel syndrome

AM Ettema, PC Amadio, C Zhao, LE Wold, KN An - JBJS, 2004 - journals.lww.com
Background: The most common histological finding in carpal tunnel syndrome is
noninflammatory synovial fibrosis. The accumulated effect of minor injuries is believed to be …

Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium

S Saika, Y Okada, T Miyamoto… - … & visual science, 2004 - iovs.arvojournals.org
purpose. The purpose of the present study was to examine the roles of signaling pathways
potentially activated by TGFβ (ie, Smad and p38 mitogen-activated kinase [MAPK]) in …

[HTML][HTML] Human corneal fibrosis: an in vitro model

D Karamichos, XQ Guo, AEK Hutcheon… - … ophthalmology & visual …, 2010 - arvojournals.org
Purpose.: Corneal injury may ultimately lead to a scar by way of corneal fibrosis, which is
characterized by the presence of myofibroblasts and improper deposition of extracellular …