Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …
tissue following injury involves dynamic interactions between multiple cell types, growth …
The airway epithelium: structural and functional properties in health and disease
The major function of the respiratory epithelium was once thought to be that of a physical
barrier. However, it constitutes the interface between the internal milieu and the external …
barrier. However, it constitutes the interface between the internal milieu and the external …
Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases
N Di Girolamo, J Chui, MT Coroneo… - Progress in retinal and …, 2004 - Elsevier
Pterygium is a common ocular surface disease apparently only observed in humans.
Chronic UV exposure is a widely accepted aetiological factor in the pathogenesis of this …
Chronic UV exposure is a widely accepted aetiological factor in the pathogenesis of this …
Identification and characterization of limbal stem cells
U Schlötzer-Schrehardt, FE Kruse - Experimental eye research, 2005 - Elsevier
The maintenance of a healthy corneal epithelium under both normal and wound healing
conditions is achieved by a population of stem cells (SC) located in the basal epithelium at …
conditions is achieved by a population of stem cells (SC) located in the basal epithelium at …
TGF-β superfamily signaling in the eye: implications for ocular pathologies
S Hachana, B Larrivée - Cells, 2022 - mdpi.com
The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …
Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy
Purpose: The corneal wound healing response is of particular relevance for refractive
surgical procedures since it is a major determinant of efficacy and safety. The purpose of this …
surgical procedures since it is a major determinant of efficacy and safety. The purpose of this …
TGFβ pathobiology in the eye
S Saika - Laboratory investigation, 2006 - nature.com
Transforming growth factor β (TGFβ), a multifunctional growth factor, is one of the most
important ligands involved in the regulation of cell behavior in ocular tissues in physiological …
important ligands involved in the regulation of cell behavior in ocular tissues in physiological …
A histological and immunohistochemical study of the subsynovial connective tissue in idiopathic carpal tunnel syndrome
Background: The most common histological finding in carpal tunnel syndrome is
noninflammatory synovial fibrosis. The accumulated effect of minor injuries is believed to be …
noninflammatory synovial fibrosis. The accumulated effect of minor injuries is believed to be …
Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium
S Saika, Y Okada, T Miyamoto… - … & visual science, 2004 - iovs.arvojournals.org
purpose. The purpose of the present study was to examine the roles of signaling pathways
potentially activated by TGFβ (ie, Smad and p38 mitogen-activated kinase [MAPK]) in …
potentially activated by TGFβ (ie, Smad and p38 mitogen-activated kinase [MAPK]) in …
[HTML][HTML] Human corneal fibrosis: an in vitro model
Purpose.: Corneal injury may ultimately lead to a scar by way of corneal fibrosis, which is
characterized by the presence of myofibroblasts and improper deposition of extracellular …
characterized by the presence of myofibroblasts and improper deposition of extracellular …