The (pro) renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form.
Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP …

The discovery of angiotensin-I-converting enzyme 2 (ACE2) and a (pro) renin receptor has
renewed interest in the physiology of the renin-angiotensin system (RAS). Through the …

The aim of this study was to explore the effects of the renin inhibitor aliskiren in
streptozotocin-diabetic TG (mRen-2) 27 rats. Furthermore, we investigated in vitro the effect …

For defining the pathogenic effects of the (pro) renin receptor–transgenic rat, strains that
overexpressed the human receptor were generated. Although transgenic rats were …

PRR [(pro) renin receptor] was named after its biological characteristics, namely the binding
of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving …

The recently cloned (pro) renin receptor [(P) RR] mediates renin-stimulated cellular effects
by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin …

A brain renin angiotensin system (RAS) and its role in cardiovascular control and fluid
homeostasis was at first controversial. This was because a circulating kidney-derived renin …

Objective Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such
binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we …

Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first
discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …