RONS and oxidative stress: An overview of basic concepts
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
[HTML][HTML] Melatonin synthesis and function: evolutionary history in animals and plants
D Zhao, Y Yu, Z Zhao, R Sharma… - Frontiers in …, 2019 - frontiersin.org
Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …
Melatonin as a hormone: new physiological and clinical insights
Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms
The neuromodulator melatonin synchronizes circadian rhythms and related physiological
functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian …
functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian …
Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …
progression and metastasis phases. In many cases, the molecular mechanisms …
Mitochondria: central organelles for melatonin′ s antioxidant and anti-aging actions
Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …
[HTML][HTML] Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …
[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease
Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
Melatonin: Physiological effects in humans
B Claustrat, J Leston - Neurochirurgie, 2015 - Elsevier
Melatonin is a methoxyindole synthesized and secreted principally by the pineal gland at
night under normal light/dark conditions. The endogenous rhythm of secretion is generated …
night under normal light/dark conditions. The endogenous rhythm of secretion is generated …
Update on melatonin receptors: IUPHAR Review 20
R Jockers, P Delagrange… - British journal of …, 2016 - Wiley Online Library
Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …