As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Tissue physical properties depend on the cells that make the tissue and also seem to be
affected by tissue use. For example, muscle, cartilage, and bone, when suitably exercised …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in
laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The nucleus of a cell has long been considered to be subject to mechanical force. Despite
the observation that mechanical forces affect nuclear geometry and movement, how forces …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Highlights•Mechanisms of nuclear size and shape regulation.•Cell cycle events that
influence nuclear morphology.•Nuclear morphology, chromatin organization, and gene …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …