Host–microbiota interactions in immune-mediated diseases

WE Ruff, TM Greiling, MA Kriegel - Nature Reviews Microbiology, 2020 - nature.com
Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

Precision microbiome modulation with discrete dietary fiber structures directs short-chain fatty acid production

EC Deehan, C Yang, ME Perez-Muñoz, NK Nguyen… - Cell host & …, 2020 - cell.com
Dietary fibers (DFs) impact the gut microbiome in ways often considered beneficial.
However, it is unknown if precise and predictable manipulations of the gut microbiota, and …

Fructose stimulated de novo lipogenesis is promoted by inflammation

J Todoric, G Di Caro, S Reibe, DC Henstridge… - Nature …, 2020 - nature.com
Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA)
oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A …

Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Dietary fructose and the metabolic syndrome

MR Taskinen, CJ Packard, J Borén - Nutrients, 2019 - mdpi.com
Consumption of fructose, the sweetest of all naturally occurring carbohydrates, has
increased dramatically in the last 40 years and is today commonly used commercially in soft …

Phage-mediated horizontal gene transfer and its implications for the human gut microbiome

T Borodovich, AN Shkoporov, RP Ross… - Gastroenterology …, 2022 - academic.oup.com
Horizontal gene transfer (HGT) in the microbiome has profound consequences for human
health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity …

[HTML][HTML] New insights into intestinal phages

R Sausset, MA Petit, V Gaboriau-Routhiau… - Mucosal …, 2020 - Elsevier
The intestinal microbiota plays important roles in human health. This last decade, the viral
fraction of the intestinal microbiota, composed essentially of phages that infect bacteria …

Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

PA de Jonge, K Wortelboer, TPM Scheithauer… - Nature …, 2022 - nature.com
There is significant interest in altering the course of cardiometabolic disease development
via gut microbiomes. Nevertheless, the highly abundant phage members of the complex gut …

Horizontal gene transfer among host-associated microbes

JM de Sousa, M Lourenço, I Gordo - Cell Host & Microbe, 2023 - cell.com
Horizontal gene transfer is an important evolutionary force, facilitating bacterial diversity. It is
thought to be pervasive in host-associated microbiomes, where bacterial densities are high …