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Sex-and gender-based pharmacological response to drugs
In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …
of biologic sex produces different in vivo environments for male and female cells. We dissect …
Gender differences in trauma, shock and sepsis
Despite efforts in prevention and intensive care, trauma and subsequent sepsis are still
associated with a high mortality rate. Traumatic injury remains the main cause of death in …
associated with a high mortality rate. Traumatic injury remains the main cause of death in …
An overview of the intrinsic role of citrullination in autoimmune disorders
A protein undergoes many types of posttranslation modification. Citrullination is one of these
modifications, where an arginine amino acid is converted to a citrulline amino acid. This …
modifications, where an arginine amino acid is converted to a citrulline amino acid. This …
Sex and gender aspects for patient stratification in allergy prevention and treatment
Allergies are rapidly worsening in recent decades, representing the most common
immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis …
immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis …
MS-based targeted metabolomics of eicosanoids and other oxylipins: Analytical and inter-individual variabilities
Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in
numerous physiological and pathological processes. Therefore, their quantitative profiling …
numerous physiological and pathological processes. Therefore, their quantitative profiling …
[HTML][HTML] Sex-related differences in drugs with anti-inflammatory properties
There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with
women being at significantly higher risk of adverse effects. Nevertheless, clinicians' …
women being at significantly higher risk of adverse effects. Nevertheless, clinicians' …
PPARα exacerbates Salmonella Typhimurium infection by modulating the immunometabolism and macrophage polarization
ABSTRACT Salmonella enterica serovar Typhimurium (STm) is a causative pathogen for
robust inflammatory gastrointestinal disease and can lead to systemic infection …
robust inflammatory gastrointestinal disease and can lead to systemic infection …
Cytokines and lipid mediators of inflammation in lungs of SARS-CoV-2 infected mice
Coronavirus disease 19 (COVID-19) is the clinical manifestation of severe acute respiratory
syndrome Coronavirus 2 (SARS-CoV-2) infection. A hallmark of COVID-19 is a lung …
syndrome Coronavirus 2 (SARS-CoV-2) infection. A hallmark of COVID-19 is a lung …
Eicosanoid receptors as therapeutic targets for asthma
Eicosanoids comprise a group of oxidation products of arachidonic and 5, 8, 11, 14, 17-
eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major …
eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major …
Sex differences in eicosanoid formation and metabolism: a possible mediator of sex discrepancies in cardiovascular diseases
Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …