Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets
YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
Vascular calcification and cellular signaling pathways as potential therapeutic targets
Increased vascular calcification (VC) is observed in patients with cardiovascular diseases
such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types …
such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types …
The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification
X Lin, SK Shan, F Xu, JY Zhong, F Wu, JY Duan… - Cell Death & …, 2022 - nature.com
Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease
(ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
(ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
Calciprotein particles: balancing mineral homeostasis and vascular pathology
AG Kutikhin, L Feenstra, AE Kostyunin… - … , and vascular biology, 2021 - Am Heart Assoc
Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …
Multi-parameter analysis of biobanked human bone marrow stromal cells shows little influence for donor age and mild comorbidities on phenotypic and functional …
Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are
among the most frequently tested cellular therapeutics for treating degenerative and immune …
among the most frequently tested cellular therapeutics for treating degenerative and immune …
Inflammation: a putative link between phosphate metabolism and cardiovascular disease
J Voelkl, D Egli-Spichtig, I Alesutan… - Clinical Science, 2021 - portlandpress.com
Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …
FGF23 and phosphate–cardiovascular toxins in CKD
I Vogt, D Haffner, M Leifheit-Nestler - Toxins, 2019 - mdpi.com
Elevated levels of fibroblast growth factor 23 (FGF23) and phosphate are highly associated
with increased cardiovascular disease and mortality in patients suffering from chronic kidney …
with increased cardiovascular disease and mortality in patients suffering from chronic kidney …
IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2
A Kurozumi, K Nakano, K Yamagata, Y Okada… - Bone, 2019 - Elsevier
Inflammation and vascular calcification are independent risk factors of cardiovascular
events. Vascular smooth muscle cells (VSMCs) exhibit osteoblast-like characteristics in …
events. Vascular smooth muscle cells (VSMCs) exhibit osteoblast-like characteristics in …
The impact of uremic toxins on vascular smooth muscle cell function
Chronic kidney disease (CKD) is associated with profound vascular remodeling, which
accelerates the progression of cardiovascular disease. This remodeling is characterized by …
accelerates the progression of cardiovascular disease. This remodeling is characterized by …
Regulation of vascular calcification by reactive oxygen species
Vascular calcification is the deposition of hydroxyapatite crystals in the medial or intimal
layers of arteries that is usually associated with other pathological conditions including but …
layers of arteries that is usually associated with other pathological conditions including but …