Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
functions and vascular biology/pathobiology in health and disease. The flow patterns and …
Mechanical regulation of chromatin and transcription
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
Cell type-specific roles of NF-κB linking inflammation and thrombosis
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior
Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications
The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein
B–containing lipoproteins. Local biological responses to these retained lipoproteins …
B–containing lipoproteins. Local biological responses to these retained lipoproteins …
Mechanotransduction in vascular physiology and atherogenesis
C Hahn, MA Schwartz - Nature reviews Molecular cell biology, 2009 - nature.com
Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …
An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
Endothelial fluid shear stress sensing in vascular health and disease
Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …
biochemical signals that regulate gene expression and cell behavior via specialized …
Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate …
Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …
progression and dissemination. Insight in cell-to-cell communication networks provides new …
Flow-induced reprogramming of endothelial cells in atherosclerosis
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …
artery disease continue to be leading causes of death worldwide despite the success of …