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Pathogenesis of respiratory viral and fungal coinfections
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for develo** invasive fungal infections. Influenza virus is one of the most …
“at risk” groups for develo** invasive fungal infections. Influenza virus is one of the most …
Targeting phospholipase D in cancer, infection and neurodegenerative disorders
Lipid second messengers have essential roles in cellular function and contribute to the
molecular mechanisms that underlie inflammation, malignant transformation, invasiveness …
molecular mechanisms that underlie inflammation, malignant transformation, invasiveness …
The phospholipase D superfamily as therapeutic targets
The phospholipase D (PLD) lipid-signaling enzyme superfamily has long been studied for its
roles in cell communication and a wide range of cell biological processes. With the advent of …
roles in cell communication and a wide range of cell biological processes. With the advent of …
Alveolar macrophages prevent lethal influenza pneumonia by inhibiting infection of type-1 alveolar epithelial cells
A Cardani, A Boulton, TS Kim, TJ Braciale - PLoS pathogens, 2017 - journals.plos.org
The Influenza A virus (IAV) is a major human pathogen that produces significant morbidity
and mortality. To explore the contribution of alveolar macrophages (AlvMΦs) in regulating …
and mortality. To explore the contribution of alveolar macrophages (AlvMΦs) in regulating …
Modeling influenza virus infection: a roadmap for influenza research
Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …
Mammalian phospholipase D: Function, and therapeutics
Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
Lipid Composition of the Viral Envelope of Three Strains of Influenza Virus Not All Viruses Are Created Equal
Although differences in the rate of virus fusion and budding from the host cell membrane
have been correlated with pathogenicity, no systematic study of the contribution of …
have been correlated with pathogenicity, no systematic study of the contribution of …
Molecular responses of agroinfiltrated Nicotiana benthamiana leaves expressing suppressor of silencing P19 and influenza virus‐like particles
LP Hamel, R Tardif, F Poirier‐Gravel… - Plant Biotechnology …, 2024 - Wiley Online Library
The production of influenza vaccines in plants is achieved through transient expression of
viral hemagglutinins (HAs), a process mediated by the bacterial vector Agrobacterium …
viral hemagglutinins (HAs), a process mediated by the bacterial vector Agrobacterium …
Lung aerosol dynamics of airborne influenza A virus-laden droplets and the resultant immune system responses: An in silico study
Abstract Influenza A Virus (IAV) replications start from the deposition of inhaled virus-laden
droplets on the epithelial cells in the pulmonary tracts. In order to understand the local …
droplets on the epithelial cells in the pulmonary tracts. In order to understand the local …
Physiological and pathophysiological roles for phospholipase D
Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles
that extend from generating the second messenger signaling lipid, phosphatidic acid …
that extend from generating the second messenger signaling lipid, phosphatidic acid …