Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs)
have also been adopted by healthy individuals to prevent being overweight. Herein, we …

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …

PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy.
However, their functions and molecular mechanisms remain unknown. Here, we identified a …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail,
chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes,
which have specific and critical functions in development and tissue homeostasis. Mounting …