The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …

Background L-carnitine (LC) is used as a supplement by recreationally-active, competitive
and highly trained athletes. This systematic review aims to evaluate the effect of prolonged …

Kidney failure and associated uraemia have implications for the cardiovascular system,
brain, and blood–brain barrier (BBB). We aim to examine BBB disruption, by assessing brain …

Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …

We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link
between diet, the gut microbiota and CVD. Generated primarily from dietary choline and …

The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was
investigated by determining their protein abundance in human liver microsomes isolated …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with
increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases …

Risdiplam (Evrysdi) improves motor neuron function in patients with spinal muscular atrophy
(SMA) and has been approved for the treatment of patients≥ 2 months old. Risdiplam …

The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived
mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester …