The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Protein homeostasis, or proteostasis, is essential for cell function, development, and
organismal viability. The composition of the proteome is adjusted to the specific …

Recent studies have indicated that the development of acute and chronic kidney disease
including renal fibrosis is associated with endoplasmic reticulum (ER) stress. S100 calcium …

Severe traumatic spinal cord injury (SCI) leads to long-lasting oligodendrocyte death and
extensive demyelination in the lesion area. Oligodendrocyte progenitor cells (OPCs) are the …

Use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of
colorectal cancer (CRC). However, the mechanism by which NSAIDs suppress colorectal …

Key points Endoplasmic reticulum (ER) stress promotes placental dysmorphogenesis and is
associated with poor pregnancy outcomes. We show that unfolded protein response …

Oxidative stress is an imbalance between the increased production of reactive species and
reduced antioxidant activity, which can cause a variety of disturbances including ocular …

During embryonic stages, vascular endothelial cells (ECs) originate from the mesoderm, at
specific extraembryonic and embryonic regions, through a process called vasculogenesis. In …

Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka
transcription factors. Reprogramming requires both epigenetic landscape resha** and …

The interaction of tumor cells with the extracellular matrix (ECM) may affect the rate of cancer
progression and metastasis. One of the major components of ECM are laminins, the …