CD4+ T cells in cancer

DE Speiser, O Chijioke, K Schaeuble, C Münz - Nature cancer, 2023‏ - nature.com
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …

Regulatory mechanisms of PD-1/PD-L1 in cancers

X Lin, K Kang, P Chen, Z Zeng, G Li, W **ong, M Yi… - Molecular Cancer, 2024‏ - Springer
Immune evasion contributes to cancer growth and progression. Cancer cells have the ability
to activate different immune checkpoint pathways that harbor immunosuppressive functions …

Immune determinants of the pre-metastatic niche

L Patras, L Shaashua, I Matei, D Lyden - Cancer Cell, 2023‏ - cell.com
Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

H Chen, T Li, Z Liu, S Tang, J Tong, Y Tao… - Nature …, 2023‏ - nature.com
The major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor
sites accurately and properly activate complex immune responses. Herein, we design and …

Pancreatic cancer stroma: an update on therapeutic targeting strategies

AN Hosein, RA Brekken, A Maitra - Nature reviews Gastroenterology & …, 2020‏ - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

WS Lee, H Yang, HJ Chon, C Kim - Experimental & molecular medicine, 2020‏ - nature.com
Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …

Anti-angiogenic agents—overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

ZR Huinen, EJM Huijbers, JR van Beijnum… - Nature Reviews …, 2021‏ - nature.com
Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

Targeting the tumour vasculature: from vessel destruction to promotion

S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024‏ - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

A Cachot, M Bilous, YC Liu, X Li, M Saillard… - Science …, 2021‏ - science.org
CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover,
their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining …

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

JD Martin, H Cabral, T Stylianopoulos… - Nature reviews Clinical …, 2020‏ - nature.com
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …