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Phosphatidylcholine-derived lipid mediators: the crosstalk between cancer cells and immune cells
To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …
mechanisms that depend on an energy trade-off between resistance and essential functions …
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …
both in development and in pathological conditions. Here, we review the literature about the …
The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors
Innate and adaptive immune cells patrol and survey throughout the human body and
sometimes reside in the tumor microenvironment (TME) with a variety of cell types and …
sometimes reside in the tumor microenvironment (TME) with a variety of cell types and …
Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
[HTML][HTML] Targeting lipid metabolism of macrophages: A new strategy for tumor therapy
N Shao, H Qiu, J Liu, D **ao, J Zhao, C Chen… - Journal of Advanced …, 2025 - Elsevier
Background Lipid metabolism has been implicated in a variety of normal cellular processes
and strongly related to the development of multiple diseases, including tumor. Tumor …
and strongly related to the development of multiple diseases, including tumor. Tumor …
[HTML][HTML] Autotaxin–Lysophosphatidate axis: promoter of cancer development and possible therapeutic implications
Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …
[HTML][HTML] Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer
Ovarian cancer (OCa) is the most lethal gynecologic cancer. Emerging data indicates that
estrogen receptor beta (ERβ) functions as a tumor suppressor in OCa. Lysine-specific …
estrogen receptor beta (ERβ) functions as a tumor suppressor in OCa. Lysine-specific …
Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic …
Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades.
However, a significant proportion of patients remain unresponsive, largely due to the …
However, a significant proportion of patients remain unresponsive, largely due to the …
Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …