Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

K Essuman, J Milbrandt, JL Dangl, MT Nishimura - Science, 2022 - science.org
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …

Activation and regulation of NLR immune receptor networks

J Kourelis, H Adachi - Plant and Cell Physiology, 2022 - academic.oup.com
Plants have many types of immune receptors that recognize diverse pathogen molecules
and activate the innate immune system. The intracellular immune receptor family of …

Pangenomic analysis reveals plant NAD+ manipulation as an important virulence activity of bacterial pathogen effectors

MT Hulin, L Hill, JDG Jones… - Proceedings of the …, 2023 - National Acad Sciences
Nicotinamide adenine dinucleotide (NAD+) has emerged as a key component in prokaryotic
and eukaryotic immune systems. The recent discovery that Toll/interleukin-1 receptor (TIR) …

Connecting the dots between cell surface-and intracellular-triggered immune pathways in plants

M Bernoux, H Zetzsche, J Stuttmann - Current Opinion in Plant Biology, 2022 - Elsevier
Plants can detect microbial molecules via surface-localized pattern-recognition receptors
(PRRs) and intracellular immune receptors from the nucleotide-binding, leucine-rich repeat …

Apprehending the NAD+–ADPr-Dependent Systems in the Virus World

LM Iyer, AM Burroughs, V Anantharaman, L Aravind - Viruses, 2022 - mdpi.com
NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host
conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and …

NAD+ depletion and defense in bacteria

M Wang, Q Ji, P Liu, Y Liu - Trends in Microbiology, 2023 - cell.com
Depletion of nicotinamide adenine dinucleotide (NAD+), an important regulator of cellular
energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both …

The Nucleotide Revolution: Immunity at the Intersection of Toll/Interleukin-1 Receptor Domains, Nucleotides, and Ca2+

S Eastman, A Bayless, M Guo - Molecular Plant-Microbe …, 2022 - Am Phytopath Society
The discovery of the enzymatic activity of the toll/interleukin-1 receptor (TIR) domain protein
SARM1 five years ago preceded a flood of discoveries regarding the nucleotide substrates …

[PDF][PDF] Pangenomics facilitated with structural analysis reveals host NAD+ 1 manipulation as a major virulence activity of bacterial effectors 2 3 Short title: Bacterial …

MT Hulin, W Ma - 2022 - researchgate.net
Hulin and Ma - main text 0806 Page 1 1 Title: Pangenomics facilitated with structural analysis
reveals host NAD+ 1 manipulation as a major virulence activity of bacterial effectors 2 3 Short …

Characterization of two regulators in plant immune receptor-mediated defense

K Ao - 2022 - open.library.ubc.ca
Plants possess a complex multi-layered immune system that enables them to defend
themselves against many potential invaders. However, some virulent pathogens can …