The HPV E6/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets
K Hoppe-Seyler, F Bossler, JA Braun, AL Herrmann… - Trends in …, 2018 - cell.com
Human papillomavirus (HPV)-induced cancers are expected to remain a major health
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …
The role of integration in oncogenic progression of HPV-associated cancers
AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …
can promote the development of cancer. In these cancers, the extrachromosomal viral …
Human viral oncogenesis: a cancer hallmarks analysis
Approximately 12% of all human cancers are caused by oncoviruses. Human viral
oncogenesis is complex, and only a small percentage of the infected individuals develop …
oncogenesis is complex, and only a small percentage of the infected individuals develop …
Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
Replicative senescence limits the proliferation of somatic cells passaged in culture and may
reflect cellular aging in vivo. The most widely used biomarker for senescent and aging cells …
reflect cellular aging in vivo. The most widely used biomarker for senescent and aging cells …
Human papillomavirus genomics: Understanding carcinogenicity
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease
High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative
agents of cervical carcinomas and are linked to several other tumors of the anogenital and …
agents of cervical carcinomas and are linked to several other tumors of the anogenital and …
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
The HeLa cell line was established in 1951 from cervical cancer cells taken from a patient,
Henrietta Lacks. This was the first successful attempt to immortalize human-derived cells in …
Henrietta Lacks. This was the first successful attempt to immortalize human-derived cells in …
The molecular biology of cancer
JS Bertram - Molecular aspects of medicine, 2000 - Elsevier
The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …
known to require the sequential acquisition of mutations which arise as a consequence of …
Pathogenesis of human papillomaviruses in differentiating epithelia
MS Longworth, LA Laimins - Microbiology and molecular biology …, 2004 - Am Soc Microbiol
Human papillomaviruses (HPV) are the etiological agents of cervical and other anogenital
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
Tumor cell senescence in cancer treatment
IB Roninson - Cancer research, 2003 - AACR
Cell senescence is broadly defined as the physiological program of terminal growth arrest,
which can be triggered by alterations of telomeres or by different forms of stress. Neoplastic …
which can be triggered by alterations of telomeres or by different forms of stress. Neoplastic …