A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

Abstract Uncoupling protein 1 (UCP1) is an integral membrane protein found in the
mitochondrial inner membrane of brown adipose tissue, and facilitates the process of non …

Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

Membrane uncoupling protein 3 (UCP3), a member of the mitochondrial uncoupling protein
family, was discovered in 1997. UCP3′ s properties, such as its high homology to other …

G protein-coupled receptors (GPCRs) are integral membrane proteins that play a pivotal role
in signal transduction. Understanding their dynamics is absolutely required to get a clear …

Adaptive thermogenesis regulates core body temperature, controls fat deposition, and
contributes strongly to the overall energy balance. This process occurs in brown fat and …

Amphipathic styrene-maleic acid (SMA) copolymers directly solubilize biomembranes into
SMA-lipid particles, or SMALPs, that are often regarded as nanodiscs and hailed as a native …

The structure, dynamics, and function of membrane proteins are intimately linked to the
properties of the membrane environment in which the proteins are embedded. For structural …

Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive
proton leak across the mitochondrial inner membrane of brown adipose tissue to produce …