[HTML][HTML] Menin Inhibitors: New Targeted Therapies for Specific Genetic Subtypes of Difficult-to-Treat Acute Leukemias
P Niscola, V Gianfelici, M Giovannini, D Piccioni… - …, 2025 - pmc.ncbi.nlm.nih.gov
Menin (MEN1) is a well-recognized powerful tumor promoter in acute leukemias (AL) with
KMT2A rearrangements (KMT2Ar, also known as MLL) and mutant nucleophosmin 1 …
KMT2A rearrangements (KMT2Ar, also known as MLL) and mutant nucleophosmin 1 …
Synthesis, characterization, and biological activities investigation of tri-armed structure of (7-bromo-5-chloro-2, 3-dihydrophthalazine-1, 4-dione) based on benzene …
MM Farhan, MA Hussein… - Journal of Chemical …, 2024 - journals.sagepub.com
Due to the importance of heterocyclic rings in drug design, we synthesized a novel
multicyclic heterocyclic compound, designated as (2, 2′, 2ʺ-(benzene-1, 3, 5-tricarbonyl) …
multicyclic heterocyclic compound, designated as (2, 2′, 2ʺ-(benzene-1, 3, 5-tricarbonyl) …
A comprehensive high-throughput screening approach for discovering inhibitors targeting the menin-MLL1 interaction
T Loganathan - Advances in protein chemistry and …, 2025 - pubmed.ncbi.nlm.nih.gov
The prognosis for mixed-lineage leukemia (MLL), particularly in young children, remains a
significant health concern due to the limited therapeutic options available. MLL refers to …
significant health concern due to the limited therapeutic options available. MLL refers to …
[PDF][PDF] Molecular Docking, ADMET & DFT Predictions of Cinnamomum zylanicum for Prostate Cancer Inhibition
AC Blessing, KG Ijeoma, IUP JM, IC BC - cancer cells - researchgate.net
The prostate gland found in men helps in semen production. When the prostate gland
enlarges out of control, it could lead to prostate cancer. Cinnamomum zeylanicum (CZ) is a …
enlarges out of control, it could lead to prostate cancer. Cinnamomum zeylanicum (CZ) is a …