Fungal pigments and their roles associated with human health

L Lin, J Xu - Journal of Fungi, 2020 - mdpi.com
Fungi can produce myriad secondary metabolites, including pigments. Some of these
pigments play a positive role in human welfare while others are detrimental. This paper …

The emerging role of nutraceuticals and phytochemicals in the prevention and treatment of Alzheimer's disease

C Calfio, A Gonzalez, SK Singh… - Journal of …, 2020 - content.iospress.com
One of the major challenges of medical sciences has been finding a reliable compound for
the pharmacological treatment of Alzheimer's disease (AD). As most of the drugs directed to …

Recent advancement in therapeutic strategies for Alzheimer's disease: insights from clinical trials

T Khan, R Waseem, M Shahid, J Ansari… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …

Harnessing neuroplasticity: modern approaches and clinical future

AO Sasmita, J Kuruvilla, APK Ling - International Journal of …, 2018 - Taylor & Francis
Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers

SK Sonawane, AA Balmik, D Boral… - Archives of biochemistry …, 2019 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder caused by protein misfolding,
aggregation and accumulation in the brain. A large number of molecules are being …

New features about tau function and dysfunction

M Medina, F Hernández, J Avila - Biomolecules, 2016 - mdpi.com
Tau is a brain microtubule-associated protein that directly binds to a microtubule and
dynamically regulates its structure and function. Under pathological conditions, tau self …

Neem derivatives inhibits tau aggregation

NV Gorantla, R Das, FA Mulani… - Journal of …, 2019 - content.iospress.com
Tau is a phosphoprotein with natively unfolded conformation that functions to stabilize
microtubules in axons. Alzheimer's disease pathology triggers several modifications in tau …

Molecular cobalt (II) complexes for tau polymerization in Alzheimer's disease

NV Gorantla, VG Landge, PG Nagaraju… - ACS …, 2019 - ACS Publications
Tau is an axonal protein known to form abnormal aggregates and is the biomarker of
Alzheimer's disease. Metal-based therapeutics for inhibition of Tau aggregation is limited …

Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

VG KrishnaKumar, A Paul, E Gazit, D Segal - Scientific Reports, 2018 - nature.com
Intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of
Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric …

Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi

T Hebra, N Pollet, D Touboul, V Eparvier - Scientific Reports, 2022 - nature.com
We gathered a collection of termite mutualistic strains from French Guiana to explore the
metabolites of symbiotic microorganisms. Molecular networks reconstructed from a …