Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Adoptive cell therapy (ACT) using ex vivo–expanded tumor-infiltrating lymphocytes (TILs)
can eliminate or shrink metastatic melanoma, but its long-term efficacy remains limited to a …

Abstract Characterization of somatic mutations at single-cell resolution is essential to study
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …

The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and
genotype, and the phenotypic and evolutionary consequences of such variation, are poorly …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Advanced high-grade serous ovarian cancer (HGSC) is an aggressive disease that
accounts for 70% of all ovarian cancer deaths. Nevertheless, 15% of patients diagnosed …

The digitization of health records and growing availability of tumour DNA sequencing
provide an opportunity to study the determinants of cancer outcomes with unprecedented …